Purpose: To investigate the relationship of myelin content, axonal density, and,gliosts with the fraction of macromolecular protons (f(B)) and T-2 relaxation of the macromolecular pool (T-2B) acquired using quantitative magnetization transfer (qMT) MRI in postmortem brains of subjects with multiple. sclerosis (MS). Materials and Methods: f(B) and T-2B were acquired unfixed fixed postmortem brain, slices, of 20 subjects with MS. The myelin content, axonal count, and of gliosis Were, all quantified histologically. t-Tests and multiple regression were used for analysis. Results: MR indices obialned in unfixed postmortem brains were consistent with in vivo values reported in the literature. A significant, correlation was detected between Tr-(myelin) (inversely proportional to myelin content) and 1) f(B) (r = -0.80, P
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